PLATELETS IN HEIGHT
Friday, August 28, 2009
Storage Auctions Pittsburgh 2010
Platelets adhere to clot
Blood Platelets PLATELET DECREASE TO ASCEND TO THE HEIGHT
The platelets or platelet cells are
3-u (microns) in diameter found in the blood. Are irregular, with no nucleus or other organelles. Have an average life of 7 to 10 days. Are very important in blood clotting ability to add each other in response to various stimuli. Clots because they have granules of active substances of coagulation. Her normal figure is between 150 000 and 400 000 per mm3. Meet
an important role in clotting. To that end nodes on the network form fibrin, release substances important to accelerate and increase clotting of the blood clot retraction.
Platelets play a fundamental role in hemostasis and are a natural source of growth factors. These growth factors have been shown to play an important role in the processes of repair and regeneration of connective tissues. Other growth factors produced by platelets and associated with healing processes include growth factor basic fibroblast growth factor-1 associated with insulin, epithelial growth factor, hepatocyte growth factor and vascular endothelial growth factor vascular.
The decreased platelet count (thrombocytopenia) when ascending to high altitude:
Gray, 1975 studied 14 men and found a drop in platelet count in 7% after two days at 2900 meters. After two additional days at 5370 m, the reduction was 25% compared with control values, but after 8 days of stay the platelet count rose to a level only 7% below the baseline.
This reduction in the number of platelets was confirmed in several experiments in rats. Birks 1975 found a slight decrease in platelets during the first 5 days of hypoxia, whereas the life span of platelets in rodents is only 4 to 5 days, one can assume that the decrease in platelet count is not destruction.
Thrombocytopenia appears to be due to a decreased number of platelets due to hypoxia .
Thrombocytopenia in the high altitude, despite being smaller in magnitude, in some ways analogous to the decreased number of blood platelets that occurs in divers subjected decompression. In this situation the thrombocytopenia is associated with asymptomatic bubbles, which can cause platelet adherence to them. Although not well established this premise bubble-platelet aggregates, seems to form microemboli that would be filtered by the pulmonary vascular network.
In patients with significant pulmonary hypertension and in cases of altitude pulmonary edema, the electrophoretic mobility of platelets is decreased. However, no ultrastructural abnormalities have been reported in platelets. You have found intact plasma membrane, the ability to form pseudopodia and the ability to degranulation.
(based on Man at High Altitude, D. Heath)
3-u (microns) in diameter found in the blood. Are irregular, with no nucleus or other organelles. Have an average life of 7 to 10 days. Are very important in blood clotting ability to add each other in response to various stimuli. Clots because they have granules of active substances of coagulation. Her normal figure is between 150 000 and 400 000 per mm3. Meet
an important role in clotting. To that end nodes on the network form fibrin, release substances important to accelerate and increase clotting of the blood clot retraction.
Platelets play a fundamental role in hemostasis and are a natural source of growth factors. These growth factors have been shown to play an important role in the processes of repair and regeneration of connective tissues. Other growth factors produced by platelets and associated with healing processes include growth factor basic fibroblast growth factor-1 associated with insulin, epithelial growth factor, hepatocyte growth factor and vascular endothelial growth factor vascular.
The decreased platelet count (thrombocytopenia) when ascending to high altitude:
Gray, 1975 studied 14 men and found a drop in platelet count in 7% after two days at 2900 meters. After two additional days at 5370 m, the reduction was 25% compared with control values, but after 8 days of stay the platelet count rose to a level only 7% below the baseline.
This reduction in the number of platelets was confirmed in several experiments in rats. Birks 1975 found a slight decrease in platelets during the first 5 days of hypoxia, whereas the life span of platelets in rodents is only 4 to 5 days, one can assume that the decrease in platelet count is not destruction.
Thrombocytopenia appears to be due to a decreased number of platelets due to hypoxia .
Thrombocytopenia in the high altitude, despite being smaller in magnitude, in some ways analogous to the decreased number of blood platelets that occurs in divers subjected decompression. In this situation the thrombocytopenia is associated with asymptomatic bubbles, which can cause platelet adherence to them. Although not well established this premise bubble-platelet aggregates, seems to form microemboli that would be filtered by the pulmonary vascular network.
In patients with significant pulmonary hypertension and in cases of altitude pulmonary edema, the electrophoretic mobility of platelets is decreased. However, no ultrastructural abnormalities have been reported in platelets. You have found intact plasma membrane, the ability to form pseudopodia and the ability to degranulation.
(based on Man at High Altitude, D. Heath)
Dr. Achilles MONROY
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