INFARCTION SPLEEN AND EXPOSURE TO HIGH
The spleen is an organ of soft consistency, located in the upper left of the abdominal cavity, in contact with the pancreas, diaphragm and kidney left. Although their size varies from person to person usually has a length of 14 cm, a width of 10 cm and a thickness of 3.8 cm and weighing approximately 200 grams. Its main function is the destruction of old red blood cells, produce some new and maintain a reserve of blood. It is part of the lymphatic system and is the center of activity of the immune system.
Several studies have described infarto espontáneo del bazo relacionado al hecho de ascender a la altura o al ejercicio. Aunque es una condición rara, es una complicación grave de la hemoglobinopatía S con células falciformes.
Estudios peruanos de pacientes expuestos a la altura mayor de 3500 msnm., como el del Oscar Frisancho (Puno, 10 casos, 1984), Braulio Calisaya (8 casos en Puno, 1996), Semba Ruiz (1 caso de Casapalca, 2006), Douglas Lopez (3 casos Huaraz 2009) y así mismo estudios latinoamericanos como el de José Tapia, Mérida Venezuela (10 casos a 1600 msnm, 2006) y otros han encontrado que la mayoría de estos pacientes tenían un ancestro africano, en quienes predomina una hemoglobinopatía S.
The abnormal hemoglobin S causes red blood cell deformation:
spleen infarction manifested by pain in the left upper quadrant, splenomegaly, fever and leukocytosis with left shift. Sometimes left pleural commitment. Paralytic ileus free peritoneal irritation and signs of anemia tell us splenic infarction complication: massive necrosis or spontaneous rupture.
Hemoglobin S results from the amino acid substitution (valine for glutamic acid) at position 6 of beta chain. This change causes a physical and chemical behavior different under hypoxic conditions, and may cause red blood cells containing this abnormal hemoglobin takes the form of "media luna" (sickle cell or drepapocito).
These red blood cells become rigid and brittle, and tend to stick to other blood cells, increased blood viscosity, decreased tissue perfusion and occluded blood vessels, causing ischemia and infarction in many organs, in this case myocardial Acute spleen.
mention The various communications concerning that a large percentage requiring emergency surgical treatment, some medical treatment, oxygen therapy, bed rest and move to low altitude recovery.
acute
This entity, which we have not had a chance to see, seems to be in Peru relating to its history. S hemoglobinopathy is an inherited disorder. The subjects are usually asymptomatic at sea level, but the move to match potentially fatal complications if not treated in time.
Knowing that most slaves brought to Peru in the colonial era were mainly from the west coast of Africa, where 12 to 36% of the population are carriers of this abnormal hemoglobin, Oscar and David Frisancho, prestigious researchers Height medicine in Peru, article "The Hb S and the failure of African labor in the mining of the colonial era" reviewed the hemoglobin S, played a major role in the high mortality rate showed a significant sector of the black population when exposed to the highlands of Peru and postulated that the interaction of biological and geographical factors, to the failure of the English crown to enforce African labor in the exploitation of rich mineral veins of the Andes, as they did in other regions.
hemoglobinopathy Summary S, Depranocytosis or Sickle Cell Disease is the most common hemoglobinopathy in the world. In its heterozygous form (Sickle Cell Trait), it affects 8% of the black population in the U.S. and 25% of the black population in Latin America. There is a substitution of glutamic acid by valin in the sixth position of the beta globin chain, which causes polymerization at low oxygen tension thereby distorting the structure of erythrocytes and increasing blood viscosity, which, in turn, generates obstructions of the capillary arterial blood flow to different areas of the body thus causing microinfarctions. Although Splenic Infarction is rare, it is recognized as a serious complication of Heterozygous Sickle Cell Disease (Sickle Cell Trait). High altitude peruvian cases are commented.
Several studies have described infarto espontáneo del bazo relacionado al hecho de ascender a la altura o al ejercicio. Aunque es una condición rara, es una complicación grave de la hemoglobinopatía S con células falciformes.
Estudios peruanos de pacientes expuestos a la altura mayor de 3500 msnm., como el del Oscar Frisancho (Puno, 10 casos, 1984), Braulio Calisaya (8 casos en Puno, 1996), Semba Ruiz (1 caso de Casapalca, 2006), Douglas Lopez (3 casos Huaraz 2009) y así mismo estudios latinoamericanos como el de José Tapia, Mérida Venezuela (10 casos a 1600 msnm, 2006) y otros han encontrado que la mayoría de estos pacientes tenían un ancestro africano, en quienes predomina una hemoglobinopatía S.
The abnormal hemoglobin S causes red blood cell deformation:
spleen infarction manifested by pain in the left upper quadrant, splenomegaly, fever and leukocytosis with left shift. Sometimes left pleural commitment. Paralytic ileus free peritoneal irritation and signs of anemia tell us splenic infarction complication: massive necrosis or spontaneous rupture.
Hemoglobin S results from the amino acid substitution (valine for glutamic acid) at position 6 of beta chain. This change causes a physical and chemical behavior different under hypoxic conditions, and may cause red blood cells containing this abnormal hemoglobin takes the form of "media luna" (sickle cell or drepapocito).
These red blood cells become rigid and brittle, and tend to stick to other blood cells, increased blood viscosity, decreased tissue perfusion and occluded blood vessels, causing ischemia and infarction in many organs, in this case myocardial Acute spleen.
mention The various communications concerning that a large percentage requiring emergency surgical treatment, some medical treatment, oxygen therapy, bed rest and move to low altitude recovery.
acute
This entity, which we have not had a chance to see, seems to be in Peru relating to its history. S hemoglobinopathy is an inherited disorder. The subjects are usually asymptomatic at sea level, but the move to match potentially fatal complications if not treated in time.
Knowing that most slaves brought to Peru in the colonial era were mainly from the west coast of Africa, where 12 to 36% of the population are carriers of this abnormal hemoglobin, Oscar and David Frisancho, prestigious researchers Height medicine in Peru, article "The Hb S and the failure of African labor in the mining of the colonial era" reviewed the hemoglobin S, played a major role in the high mortality rate showed a significant sector of the black population when exposed to the highlands of Peru and postulated that the interaction of biological and geographical factors, to the failure of the English crown to enforce African labor in the exploitation of rich mineral veins of the Andes, as they did in other regions.
Dr. Achilles MONROY
hemoglobinopathy Summary S, Depranocytosis or Sickle Cell Disease is the most common hemoglobinopathy in the world. In its heterozygous form (Sickle Cell Trait), it affects 8% of the black population in the U.S. and 25% of the black population in Latin America. There is a substitution of glutamic acid by valin in the sixth position of the beta globin chain, which causes polymerization at low oxygen tension thereby distorting the structure of erythrocytes and increasing blood viscosity, which, in turn, generates obstructions of the capillary arterial blood flow to different areas of the body thus causing microinfarctions. Although Splenic Infarction is rare, it is recognized as a serious complication of Heterozygous Sickle Cell Disease (Sickle Cell Trait). High altitude peruvian cases are commented.
